abstract：:We have shown previously that the plecomacrolide antibiotics bafilomycin A1 and B1 significantly attenuate cerebellar granule neuron death resulting from agents that disrupt lysosome function. To further characterize bafilomycin-mediated cytoprotection, we examined its ability to attenuate the death of naïve and diffe...

journal_title：Journal of neurochemistry

authors： Pivtoraiko VN,Harrington AJ,Mader BJ,Luker AM,Caldwell GA,Caldwell KA,Roth KA,Shacka JJ

更新日期：2010-08-01 00:00:00

abstract：:Wallerian degeneration in peripheral nerves occurs after a traumatic insult when the distal nerve part degenerates while peripheral macrophages enter the nerve stump and remove the accruing debris by phagozytosis. We used an experimental model to investigate the effect of either the absence or over-expression of alpha...

journal_title：Journal of neurochemistry

authors： Siebert H,Kahle PJ,Kramer ML,Isik T,Schlüter OM,Schulz-Schaeffer WJ,Brück W

更新日期：2010-08-01 00:00:00

abstract：:Despite the increasing knowledge of Alzheimer's disease (AD) management with novel pharmacologic agents, most of them are only transiently fixing symptomatic pathology. Currently there is rapid growth in the field of neuroprotective pharmacology and increasing focus on the involvement of mitochondria in this devastati...

journal_title：Journal of neurochemistry

authors： Galindo MF,Ikuta I,Zhu X,Casadesus G,Jordán J

更新日期：2010-08-01 00:00:00

abstract：:Our previous observations have shown that neuroactive steroid levels in the brain are affected by acute experimental autoimmune encephalomyelitis (EAE) with sex and regional specificity (Giatti et al. 2010). To better understand the effect of EAE on neuroactive steroids, we have here assessed the levels of pregnenolon...

journal_title：Journal of neurochemistry

authors： Caruso D,D'Intino G,Giatti S,Maschi O,Pesaresi M,Calabrese D,Garcia-Segura LM,Calza L,Melcangi RC

更新日期：2010-08-01 00:00:00

abstract：:Spinocerebellar ataxia 1 (SCA1) is a dominantly inherited neurodegenerative disease associated with progressive ataxia resulting from the loss of cerebellar Purkinje cells (PCs) and neurons in the brainstem. In PCs of SCA1 transgenic mice, the disease causing ataxin-1 protein mediates the formation of S100B containing...

journal_title：Journal of neurochemistry

authors： Hearst SM,Lopez ME,Shao Q,Liu Y,Vig PJ

更新日期：2010-08-01 00:00:00

abstract：:Acetyl-L-carnitine (ALCAR) is an endogenous metabolic intermediate that facilitates the influx and efflux of acetyl groups across the mitochondrial inner membrane. Exogenously administered ALCAR has been used as a nutritional supplement and also as an experimental drug with reported neuroprotective properties and effe...

journal_title：Journal of neurochemistry

authors： Scafidi S,Fiskum G,Lindauer SL,Bamford P,Shi D,Hopkins I,McKenna MC

更新日期：2010-08-01 00:00:00

abstract：:The normal cellular form of prion protein (PrP(C)) has been shown to exhibit a diverse range of biological activities. Several recent studies highlighted potential involvement of PrP(C) in embryogenesis or in regulating stem cell self-renewal and proliferation. In the current study, we employed human embryonic stem ce...

journal_title：Journal of neurochemistry

authors： Lee YJ,Baskakov IV

更新日期：2010-07-01 00:00:00

abstract：:The double C2 (Doc2) family is characterized by an N-terminal Munc13-1-interacting domain and C-terminal tandem C2 domains, and it comprises three isoforms, Doc2alpha, Doc2beta, and Doc2gamma, in humans and mice. Doc2alpha, the best-characterized, brain-specific isoform, exhibits Ca(2+)-dependent phospholipid-binding ...

journal_title：Journal of neurochemistry

authors： Sato M,Mori Y,Matsui T,Aoki R,Oya M,Yanagihara Y,Fukuda M,Tsuboi T

更新日期：2010-07-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S), a gasotransmitter, induces neuronal differentiation characterized by neuritogenesis and functional up-regulation of high voltage-activated Ca(2+) channels, via activation of T-type Ca(2+) channels in NG108-15 cells. We thus analyzed signaling mechanisms for the H(2)S-evoked neuronal different...

journal_title：Journal of neurochemistry

authors： Tarui T,Fukami K,Nagasawa K,Yoshida S,Sekiguchi F,Kawabata A

更新日期：2010-07-01 00:00:00

abstract：:Proteins that control the excitability of neurons, including voltage-dependent ion channels and neurotransmitter receptors, reside in a membrane lipid environment that includes sphingomyelin, but the influence of the metabolism of this lipid on excitability is unknown. Sphingomyelin in the plasma membrane can be cleav...

journal_title：Journal of neurochemistry

authors： Norman E,Cutler RG,Flannery R,Wang Y,Mattson MP

更新日期：2010-07-01 00:00:00

abstract：:Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system and extracellular glutamate levels are controlled by a family of transporters known as excitatory amino acid transporters (EAATs). The EAATs transport glutamate and aspartate with similar micromolar affinities and this tra...

journal_title：Journal of neurochemistry

authors： Ryan RM,Kortt NC,Sirivanta T,Vandenberg RJ

更新日期：2010-07-01 00:00:00

abstract：:In multiple sclerosis (MS), oligodendrocytes in lesions are lost, leaving damaged tissue virtually devoid of these myelin-producing cells. Our group has recently demonstrated enhanced expression of insulin-like growth factor (IGF) binding protein-1 (IGFBP-1) in oligodendrocytes (CNPase(+)) localized adjacent to MS les...

journal_title：Journal of neurochemistry

authors： Chesik D,De Keyser J,Bron R,Fuhler GM

更新日期：2010-06-01 00:00:00

abstract：:Our previous work demonstrated that immunoproteasome is up-regulated in the retina and brain in response to injury that does not involve an inflammatory response (J. Neurochem. 2008; 106:158). These results suggest additional non-immune functions for the immunoproteasome in the cellular stress response pathway. The pr...

journal_title：Journal of neurochemistry

authors： Hussong SA,Kapphahn RJ,Phillips SL,Maldonado M,Ferrington DA

更新日期：2010-06-01 00:00:00

abstract：:Enkephalin (ENK) has been implicated in nociceptive transmission in the spinal cord while its functional role is not clear because of difficulties in ideally visualizing ENKergic neurons. We thus developed preproenkephalin-green fluorescent protein transgenic mice to better identify ENKergic neurons. Real-time reverse...

journal_title：Journal of neurochemistry

authors： Huang J,Chen J,Wang W,Wang W,Koshimizu Y,Wei YY,Kaneko T,Li YQ,Wu SX

更新日期：2010-06-01 00:00:00

abstract：:We have identified two genes from the parasitic nematode Haemonchus contortus, Hco-unc-49B and Hco-unc-49C that encode two GABA-gated chloride channel subunits. Electrophysiological analysis revealed that this channel has properties similar to those of the UNC-49 channel from the free-living nematode Caenorhabditis el...

journal_title：Journal of neurochemistry

authors： Siddiqui SZ,Brown DD,Rao VT,Forrester SG

更新日期：2010-06-01 00:00:00

abstract：:Abnormal expansion of a polyglutamine tract in huntingtin (Htt) protein results in Huntington's disease (HD), an autosomal dominant neurodegenerative disorder involving progressive loss of motor and cognitive function. Contrasting with the ubiquitous tissue expression of polyglutamine-expanded Htt, HD pathology is cha...

journal_title：Journal of neurochemistry

authors： Han I,You Y,Kordower JH,Brady ST,Morfini GA

更新日期：2010-06-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) has both soluble (S-COMT) and membrane-bound (MB-COMT) isoforms. A specific COMT antibody was used in immunohistochemical and confocal co-localization studies to explore the distribution of COMT in general in normal mice and MB-COMT in particular, in an S-COMT deficient mouse line. ...

journal_title：Journal of neurochemistry

authors： Myöhänen TT,Schendzielorz N,Männistö PT

更新日期：2010-06-01 00:00:00

abstract：:Increasing evidence suggests that glucagon-like peptide-1 (GLP-1), an incretin hormone of current interest in type 2 diabetes, is neuroprotective in both cell culture and animal models. To characterize the neuroprotective properties of GLP-1 and associated underlying mechanisms, we over-expressed the GLP-1 receptor (G...

journal_title：Journal of neurochemistry

authors： Li Y,Tweedie D,Mattson MP,Holloway HW,Greig NH

更新日期：2010-06-01 00:00:00

abstract：:Recent studies suggest that the chemotactic G protein-coupled receptor formyl-peptide-receptor-like-1 (FPRL1) or the scavenger receptor MARCO (macrophage receptor with collagenous structure) plays an essential role in the inflammatory response of host defense mechanisms and neurodegenerative disorders such as Alzheime...

journal_title：Journal of neurochemistry

authors： Brandenburg LO,Konrad M,Wruck CJ,Koch T,Lucius R,Pufe T

更新日期：2010-05-01 00:00:00

abstract：:The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of patients with Alzheimer's disease (AD). We previously ...

journal_title：Journal of neurochemistry

authors： Tian G,Kong Q,Lai L,Ray-Chaudhury A,Lin CL

更新日期：2010-05-01 00:00:00

abstract：:Lysophosphatidic acid receptor (LPA(1)) signaling initiates neuropathic pain through demyelination of the dorsal root (DR). Although LPA is found to cause down-regulation of myelin proteins underlying demyelination, the detailed mechanism remains to be determined. In the present study, we found that a single intrathec...

journal_title：Journal of neurochemistry

authors： Xie W,Uchida H,Nagai J,Ueda M,Chun J,Ueda H

更新日期：2010-05-01 00:00:00

abstract：:We investigated the regulatory pathways responsible for agonist-induced internalization and down-regulation of G(q) protein-coupled histamine H(1)-receptors in Chinese hamster ovary cells. Histamine-induced internalization and down-regulation of H(1)-receptors were detected as the loss of [(3)H]mepyramine binding site...

journal_title：Journal of neurochemistry

authors： Hishinuma S,Komazaki H,Fukui H,Shoji M

更新日期：2010-05-01 00:00:00

abstract：:The mechanisms by which chronic nicotine self-administration augments hypothalamo-pituitary-adrenal (HPA) responses to stress are only partially understood. Nicotine self-administration alters neuropeptide expression in corticotropin-releasing factor (CRF) neurons within paraventricular nucleus (PVN) and increases PVN...

journal_title：Journal of neurochemistry

authors： Yu G,Chen H,Wu X,Matta SG,Sharp BM

更新日期：2010-05-01 00:00:00

abstract：:Activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) are implicated in the pathophysiology of spinal cord injury (SCI). However, the specific functions of individual ERK isoforms in neurodegeneration are largely unknown. We investigated the hypothesis that ERK2 activation may contribute to patholog...

journal_title：Journal of neurochemistry

authors： Yu CG,Yezierski RP,Joshi A,Raza K,Li Y,Geddes JW

更新日期：2010-04-01 00:00:00

abstract：:The dopamine transporter (DAT) plays a key role in regulating dopaminergic signalling in the brain by mediating rapid clearance of dopamine from the synaptic clefts. The psychostimulatory actions of cocaine and amphetamine are primarily the result of a direct interaction of these compounds with DAT leading to attenuat...

journal_title：Journal of neurochemistry

authors： Eriksen J,Jørgensen TN,Gether U

更新日期：2010-04-01 00:00:00

abstract：:Ion channels are classically understood to regulate the flux of ions across the plasma membrane in response to a variety of environmental and intracellular cues. Ion channels serve a number of functions in intracellular membranes as well. These channels may be temporarily localized to intracellular membranes as a func...

journal_title：Journal of neurochemistry

authors： Dong XP,Wang X,Xu H

更新日期：2010-04-01 00:00:00

abstract：:In vertebrates and some invertebrates, odorant molecules bind to G protein-coupled receptors on olfactory receptor neurons (ORNs) to initiate signal transduction. Phosphoinositide 3-kinase (PI3K) activity has been implicated physiologically in olfactory signal transduction, suggesting a potential role for a G protein-...

journal_title：Journal of neurochemistry

authors： Corey EA,Bobkov Y,Pezier A,Ache BW

更新日期：2010-04-01 00:00:00

abstract：:Water-soluble iron, and manganese(III) complexes of corroles and porphyrins were examined with regard to their neuroprotective/neurorescue activities by using various neuronal cytotoxic models of oxidative and nitrative stress. The present study demonstrates that the metallocorroles significantly protect human neurobl...

journal_title：Journal of neurochemistry

authors： Kupershmidt L,Okun Z,Amit T,Mandel S,Saltsman I,Mahammed A,Bar-Am O,Gross Z,Youdim MB

更新日期：2010-04-01 00:00:00

abstract：:Published evidence has linked glutamate with the pathogenesis of Alzheimer's disease (AD) and the up-regulation of a variety of chemokines, including monocyte chemotactic protein-1 (MCP-1)/chemokine ligand 2, with AD-associated pathological changes. In this study, we assessed the potential molecular basis for the role...

journal_title：Journal of neurochemistry

authors： Lee EO,Park HJ,Kang JL,Kim HS,Chong YH

更新日期：2010-03-01 00:00:00

abstract：:There is much evidence to suggest that G protein coupled receptors exist as oligomers but the relevance to their function is unclear. We have, therefore, examined the binding of the radiolabelled agonist [(3)H]NPA to membranes of CHO cells expressing the D(2) dopamine receptor in dissociation rate experiments. When [(...

journal_title：Journal of neurochemistry

authors： Kara E,Lin H,Strange PG

更新日期：2010-03-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of angiotensin IV (Ang IV) or Leu-Val-Val-haemorphin 7 (LVV-H7) improves memory performance in normal rats and reverses memory deficits in rat models for cognitive impairment. These memory effects were believed to be mediated via the putative 'AT4 receptor'. However, thi...

journal_title：Journal of neurochemistry

authors： De Bundel D,Demaegdt H,Lahoutte T,Caveliers V,Kersemans K,Ceulemans AG,Vauquelin G,Clinckers R,Vanderheyden P,Michotte Y,Smolders I

更新日期：2010-03-01 00:00:00

abstract：:Declining levels of estrogen in women result in increases in gonadotropins such as luteinizing hormone (LH) through loss of feedback inhibition. LH, like estrogen, is modulated by hormone replacement therapy. However, the role of post-menopausal gonadotropin increases on cognition has not been evaluated. Here, we demo...

journal_title：Journal of neurochemistry

authors： Bryan KJ,Mudd JC,Richardson SL,Chang J,Lee HG,Zhu X,Smith MA,Casadesus G

更新日期：2010-02-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a popular recreational drug used worldwide. This study aimed to determine the effects of this compound on the expression of nerve terminal serotonergic markers in rats. Experiment 1 investigated MDMA-induced changes in levels of the serotonin transporter (SERT) an...

journal_title：Journal of neurochemistry

authors： Biezonski DK,Meyer JS

更新日期：2010-02-01 00:00:00

abstract：:Most recent studies aimed at defining the cellular and molecular mechanisms of Pavlovian fear conditioning have focused on protein kinase signaling pathways and the transcription factor cAMP-response element binding protein (CREB) that promote fear memory consolidation in the lateral nucleus of the amygdala (LA). Desp...

journal_title：Journal of neurochemistry

authors： Ploski JE,Park KW,Ping J,Monsey MS,Schafe GE

更新日期：2010-02-01 00:00:00

abstract：:Neurite formation involves coordinated changes between the actin cytoskeleton and the microtubule network. Rho GTPases are clearly implicated in several aspects of neuronal development and function. Indeed, RhoA is a negative regulator of neurite outgrowth and its effector Rho-kinase mediates the Rho-driven neurite re...

journal_title：Journal of neurochemistry

authors： Talens-Visconti R,Peris B,Guerri C,Guasch RM

更新日期：2010-02-01 00:00:00

abstract：:Trichloroethylene, a chlorinated solvent widely used as a degreasing agent, is a common environmental contaminant. Emerging evidence suggests that chronic exposure to trichloroethylene may contribute to the development of Parkinson's disease. The purpose of this study was to determine if selective loss of nigrostriata...

journal_title：Journal of neurochemistry

authors： Liu M,Choi DY,Hunter RL,Pandya JD,Cass WA,Sullivan PG,Kim HC,Gash DM,Bing G

更新日期：2010-02-01 00:00:00

abstract：:Microglial activation can lead to microglial apoptosis, which may serve to remove highly reactive and possibly neurotoxic microglia. However the loss of microglia may have consequences for future recovery, protection and repair. P53, a nuclear phosphoprotein transcription factor, is critical for activating the express...

journal_title：Journal of neurochemistry

authors： Davenport CM,Sevastou IG,Hooper C,Pocock JM

更新日期：2010-01-01 00:00:00

abstract：:Calcium/calmodulin-dependent kinase II (CaMKII) facilitates L-type calcium channel (LTCC) activity physiologically, but may exacerbate LTCC-dependent pathophysiology. We previously showed that CaMKII forms stable complexes with voltage-gated calcium channel (VGCC) beta(1b) or beta(2a) subunits, but not with the beta(3...

journal_title：Journal of neurochemistry

authors： Abiria SA,Colbran RJ

更新日期：2010-01-01 00:00:00

abstract：:In the last 40 years, especially with the application of new neurochemical and molecular biological techniques, there has been explosive progress in understanding how certain ligands and drugs are transported across the blood-brain barrier and choroid plexus out of brain and CSF. In the CNS, there are several separate...

journal_title：Journal of neurochemistry

authors： Spector R

更新日期：2010-01-01 00:00:00

abstract：:Cathepsin D (CTSD) deficiencies are fatal neurological diseases that in human infants and in sheep are characterized by extreme loss of neurons and myelin. To date, similar morphological evidence for myelin disruption in CTSD knockout mice has not been reported. Here, we show that CTSD deficiency leads to pronounced m...

journal_title：Journal of neurochemistry

authors： Mutka AL,Haapanen A,Käkelä R,Lindfors M,Wright AK,Inkinen T,Hermansson M,Rokka A,Corthals G,Jauhiainen M,Gillingwater TH,Ikonen E,Tyynelä J

更新日期：2010-01-01 00:00:00